[Remote] Senior Bioinformatics Scientist

Note: The job is a remote job and is open to candidates in USA. Karius is a life science, venture-backed clinical metagenomics company focused on advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. The Senior Bioinformatics Scientist will lead data analysis and interpretation of complex biological datasets, design analysis plans, and collaborate with cross-functional teams to drive biomarker discovery and precision medicine applications.

Responsibilities

• Lead data analysis and interpretation of complex biological datasets, including next-generation sequencing (NGS), metagenomics, transcriptomics, fragmentomics, and single-cell analysis.
• Create or adapt computational tools and algorithms to support biomarker discovery and workflows.
• Drive bioinformatics aspects of cross-functional research projects in collaboration with scientific and medical leaders, under the guidance of the Director of Computational Biomarker Discovery.
• Conduct deep exploration of the biological interplay between molecular data and disease conditions, generating insights to advance translational science.
• Deliver preliminary biological signatures that inform precision medicine applications beyond infectious disease, including autoimmune disorders and oncology.
• Partner in experimental design by defining analysis plans, selecting appropriate methodologies, and executing computational analyses with a strong grounding in biological rationale.
• Collaborate closely with scientific, medical, engineering, and commercial teams to set company goals and support the development of new partnerships and products.
• Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings.
• Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders.
• Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature.
• Share enthusiasm for exploring novel applications of Karius’ technology platform to drive innovation and impact.

Skills

• Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master’s degree with 5+ years of directly relevant industry experience.
• Publications demonstrating the use of innovative mathematical or computational models to investigate and interpret biological and biomarker data.
• Strong background in modern statistics and machine learning, including applications to biomarker discovery.
• Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise.
• Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams.
• Self-starter with the ability to independently drive results and influence project direction.
• Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host–environment interactions.
• Deep understanding and hands-on experience with bioinformatics tools, methods, and workflows, especially those related to next-generation sequencing (NGS) data analysis.
• Familiarity with exploratory study and clinical trial designs and analyses, particularly in pharmaceutical or biotechnology applications.
• Passionate, purpose-driven, and excited about Karius’ mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning.
• Excellence at communication and collaboration within a cross-functional team.
• Detail oriented with exceptional organizational and time management skills.
• Self-starting mentality and ability to drive results.
• Comfortable working in an environment which combines both research aspects as well as development.
• Ability to work effectively and efficiently in a fast-paced (startup) environment.

Company Overview

• Karius delivers genomic insights into infectious diseases, helping clinicians make critical, life-saving treatment decisions. It was founded in 2014, and is headquartered in Redwood City, California, USA, with a workforce of 51-200 employees. Its website is https://kariusdx.com.

Company H1B Sponsorship

• Karius has a track record of offering H1B sponsorships, with 1 in 2024, 4 in 2021. Please note that this does not guarantee sponsorship for this specific role.

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