Senior Computational Biologist

POSITION SUMMARY Our Inflammation & Immunology (I&I) unit is dedicated to developing transformative treatments for patients with autoimmune, inflammatory, and immune-mediated diseases, by understanding the pathogenic mechanisms underlying inflammation. As a Senior Computational Biologist in our Systems Immunology group, you will design and implement robust data pipelines that ensure the integrity, scalability, and reproducibility of multi-omics analyses—enabling seamless integration of genomic, transcriptomic, and proteomic data. By applying best practices in data engineering and reproducible research, you will help transform raw biological data into actionable knowledge, accelerating target discovery, biomarker identification, and indication selection, across the drug development pipeline. RESPONSIBILITIES

• Develop and maintain robust workflows for integrating diverse datasets including genomics, transcriptomics, proteomics, spatial omics, and functional genomics studies.
• Apply best practices in data management and curation; ensure data integrity, traceability, and version control.
• Promote reproducibility and transparency in computational research through standardized methods and documentation.
• Communicate methods, analytical results, and interpretation, effectively to collaborators and leadership.
• Lead and participate in project teams to mine data for new targets and inform precision medicine strategies.

MINIMUM QUALIFICATIONS

• Ph.D. in Computational Biology, Bioinformatics, Biostatistics, or a related field with relevant experience applying quantitative methods to biological questions OR
• Master’s degree with at least 3 years of relevant experience applying quantitative methods to biological questions in a pharmaceutical industry setting.
• Expertise in computational genetics and multi-omics data analysis, including the integration of genomic, transcriptomic, proteomic, spatial, and other high-dimensional datasets to uncover disease mechanisms and inform therapeutic strategies.
• Proficiency in Python and R for data analysis, with working knowledge of Linux-based systems, high-performance computing (HPC) environments, and cloud computing platforms (e.g., AWS, GCP, or Azure) to support scalable and reproducible research workflows.
• Demonstrated experience in organizing and managing complex biological datasets using reproducible research practices, including version-controlled workflows, standardized documentation, and adherence to data governance principles to ensure transparency, scalability, and scientific rigor.

PREFERRED QUALIFICATIONS

• Background in human biology or medicine, especially in immunology & inflammation.
• Familiarity with public or proprietary databases related to inflammatory diseases.
• Experience with statistical genetics, population genetics and medical genetics.
• Experience with integrating across multi-omics data types, with clinical data and real-world data.
• Experience implementing NextFlow Pipelines using AWS Batch.
• Experience using PerturbSeq data to infer causal gene regulatory networks, and/or virtual cell foundation models.
• Experience with single-cell epigenetics and/or DNA foundation models to integrate locus-to-transcript-to-phenotype relationships at scale.
• Strong quantitative skills in statistical and machine learning methods.

Relocation support available Work Location Assignment: Hybrid #LI-PFE Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. The annual base salary for this position ranges from $102,900.00 to $171,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make www.pfizer.com/careers accessible to all users. 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